1/16/2024 0 Comments Novavax company![]() Official guidelines say doses of the Pfizer-BioNTech vaccine should be given 21 days apart, while Moderna recommends spacing shots 28 days apart.Įarly findings from U.K. Pfizer's vaccine needs to remain frozen before use at –70 C, while Moderna's vaccine needs to be stored at –20 C. Maryland-based Novavax says its two-dose vaccine, which will be administered 21 days apart, remains stable at 2 C to 8 C, meaning it only needs basic refrigeration. Those vaccines give genetic instructions to the cell on how to make a piece of the spike protein that is unique to the virus that causes COVID-19. Track how many people have been given COVID-19 vaccines across Canadaīoth use messenger RNA (ribonucleic acid) technology, or mRNA, which the Centers for Disease Control says has been studied for more than a decade.Canada inks deal to produce millions of COVID-19 shots domestically.A closer look at the vaccines Canada is betting on to stem the spread of COVID-19.The Moderna and Pfizer-BioNTech vaccines, on the other hand, use a newer approach. The tried-and-true method of making a custom copy of a virus spike protein has been used to develop vaccines against HPV, hepatitis B and influenza. ![]() The company says it boosts the body's immune response and generates a bigger immune response with a lower dose. Novavax uses a proprietary adjuvant called Matrix-M, which is based on a type of compound found in many plants called a saponin. Protein subunit vaccines don't elicit as strong an immune response as whole virus vaccines, so they often include an adjuvant. When the particles are injected into the body with an adjuvant - a compound that enhances immune response - the body learns to recognize and fight off the virus. It's a protein subunit vaccine, meaning it uses nanoparticles of a lab-grown spike protein that mimics the natural spike protein on the surface of the novel coronavirus and which helps the virus bind to cells and cause infection. The Novavax vaccine, now closer to joining Canada's COVID-19 inoculation program, differs from the two vaccines Canadians are currently receiving to guard against the respiratory illness, primarily because of how it's engineered to induce an immune response in the body.
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